Protein Details: ATP-sensitive inward rectifier potassium channel 10
Protein ID
ICDB_Pro_1549
Protein Name
ATP-sensitive inward rectifier potassium channel 10
Gene Name
Kcnj10
Organism
Mus musculus (Mouse)
Length
379 amino acids
AlphaFoldDB
AF-Q9JM63-F1-model_v4.pdb
Function
May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised; the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity). In the kidney; together with KCNJ16; mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules (By similarity)
Sequence
PDB Structures
Ligand Binding
Binding Site
210..217
Disease
Location
Widely expressed in adult brain; including in the neocortex; the stratum pyrimadale of the hippocampus and the piriform cortex. Expressed by cultured astrocytes and also by cocultured cortical neurons (at protein level). Expressed in the distal segment of the nephron (PubMed:33811157).
DOI ID
10.1002/1098-1136(20010101)33:1<57::aid-glia1006>3.0.co;2-0; 10.1006/mcne.1998.0679; 10.1016/j.cell.2010.12.001; 10.1681/asn.2020111587
RefSeq
NP_001034573.1; XP_006496740.2